作者: Douglas J. Tobias , William I.-Feng Kuo , Ali Razmara , Mounir Tarek
DOI: 10.1007/978-3-662-05231-0_10
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摘要: Proteins are linear heteropolymers of amino acids connected by amide (peptide) linkages. There twenty naturally occurring whose side chains span a wide range polarity (e.g. aliphatic, aromatic, neutral polar, acidic, and basic). The polypeptide backbone is largely organized into regular “secondary” structures (α-helices, β-sheets, reverse turns) networks hydrogen bonds, along with unstructured regions (loops). Interactions between the solvent determine how secondary structural elements uniquely packed together in functional (native) state protein.