Development of a wireless swallowable capsule with potentiostatic electrochemical sensor for gastrointestinal track investigation

摘要: Abstract The gastrointestinal (GI) tract, especially the small intestine, remains largely inaccessible to modern medical science. While swallowable capsule technologies are emerging, endoscopy and colonoscopy remain primary method for GI tract analysis. This paper presents an alternative wireless device, with electrochemical sensing technique, which behaves autonomously as it travels through tract. includes a direct access, multi electrode electronic tongue sensor that enables non-specific characterization of gut fluids, aiding in diagnosis diseases such Crohn's ulcerative colitis. sensor, interfaced potentiostatic circuit, is capable performing various voltammetries cyclic, square wave differential pulse techniques. A communication link, operating at 433 MHz, delivers measured data base station receiver located outside body. capsule, powered by single lithium-ion cell implemented on polyimide flexible substrate, encapsulated polyether ether ketone (PEEK) material measure 12 mm diameter 28 mm length taking volume approximately 4 cm 3 . capsule's front end potentiostat compares well commercial laboratory equipment under same voltammetry conditions. system its application examination faecal waters proves potential vivo diagnostic tool other biomedical applications requiring miniaturized low power device.