Seipin is required for converting nascent to mature lipid droplets.

摘要: Living organisms often store energy in the form of fat molecules called triglycerides. Enzymes a compartment cell endoplasmic reticulum catalyze chemical reactions needed to make these The then stores triglycerides different structure lipid droplet. Lipid droplets from an organized manner, but little is known about cellular machinery that gives rise droplets. A protein seipin thought be involved droplet formation. Seipin resides and shortage this cells leads abnormal – is, have lots tiny or few giant ones. People who lack lose much their tissue instead wrong places, such as liver. Now, Wang et al. studied insect human grown laboratory. experiments confirmed dot-like structures containing fail grow into normal-sized These proteins on surface, which may impair ability fat. also discovered normal cells, found at distinct spots reticulum. This distribution appears allow come contact with small, newly formed enable them grow. Together findings suggest could part molecular machine allows more added causing normal. When not present initially become stuck smaller form. As consequence, later enter pathway expansion, turns abnormally large Future challenges will determine precisely how enables It important confirm whether works other and, if so, investigate affect formation growth