Remodeling With Neointima Formation in the Mouse Carotid Artery After Cessation of Blood Flow

摘要: The ability of gene targeting in the mouse species presents a powerful tool to determine role specific molecules vascular biology. Using denuding-injury procedure, we recently reported that intimal lesions can be induced carotid artery outbred mice. technical challenge associated with achieving complete denudation and relatively small size developing prompted us design present model neointima formation remodeling inbred FVB strain. Complete ligation vessel near bifurcation rapid proliferation medial smooth muscle cells, leading extensive presence an endothelial lining. Thrombus was not observed except most distal part adjacent ligature. At 4 weeks after ligation, luminal area reduced by approximately 80% through combination decreased diameter formation. Ultrastructural analysis provided evidence for cell death as well media. might useful identifying those genes important remodeling.