The role of retinoic acid related orphan receptor alpha in age-related macular degeneration
作者： Hai Hoang
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摘要: Age-related macular degeneration (AMD) is a prevalent cause of vision loss and irreversible blindness that affects more than 11 million Americans. AMD multifactorial disease with number genetic, demographic, environmental risk factors. Currently the etiology still unclear there are no effective cure for this devastating disease, but recent studies have demonstrated RORA candidate gene involved in pathophysiology. critical regulator multiple biological processes has been implicated various physiological including circadian rhythm, lipid metabolism, photoreceptor development, autism, inflammation. Our current study will explore depth role AMD. We look at effects retina mice. Localization retinal tissues obtained from mice conditional knockout epithelial cells showed little effect on structural retina. However, was decrease VEGF TGF-B proteins knockout. This an interesting finding because important function angiogenesis neovascularization which pathophysiological In addition, we try to identify targets also linked By identifying discovering how regulates these targets, hope better understand ChIP-seq software
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