Phylogenetic Profiling of Insertions and Deletions in Vertebrate Genomes
作者： Sagi Snir , Lior Pachter
DOI: 10.1007/11732990_23
关键词:
摘要: Micro-indels are small insertion or deletion events (indels) that occur during genome evolution. The study of micro-indels is important, both in order to better understand the underlying biological mechanisms, and also for improving evolutionary models used sequence alignment phylogenetic analysis. inference from multiple alignments related genomes poses a difficult computational problem, far more complicated than task inferring history point mutations. We introduce tree based approach suitable working with emphasizes concept indel history. By an appropriately restricted model, we able propose algorithm optimal homologous sequences efficient practical problems. Using data ENCODE project as well primates, compare contrast coding non-coding regions. ability work allows us refute previous claim rates approximately fixed even when mutation rate changes, show not neutral. In particular, identify hotspots human genome.
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