Parvoviral host range and cell entry mechanisms.

摘要: Abstract Parvoviruses elaborate rugged nonenveloped icosahedral capsids of ∼260 A in diameter that comprise just 60 copies a common core structural polypeptide. While serving as exceptionally durable shells, capable protecting the single‐stranded DNA genome from environmental extremes, capsid also undergoes sequential conformational changes allow it to translocate its initial host cell nucleus all way into subsequent host. Lacking duplex transcription template, virus must then wait for enter S‐phase before can initiate and usurp cell's synthetic pathways. Here we review entry mechanisms used by parvoviruses. We explore two apparently distinct modes specificity, first Minute mice, where subtle glycan‐specific interactions between receptors residues surrounding twofold symmetry axes on virion surface mediate differentiated type target while second involves novel protein with canine transferrin receptor mutant feline leukopenia serotype, Canine parvovirus, bind infect dog cells. discuss shifts accompany entry, causing exposure capsid‐tethered phospholipase A2 enzymatic acts an endosomolytic agent translocation across lipid bilayer cytoplasm. Finally, delivery nucleus, consider nature transcriptionally silent species that, escaping detection cell, might unhampered progress hence unleash parvoviral Trojan horse.