Nature-based molecules combined with rivastigmine: A symbiotic approach for the synthesis of new agents against Alzheimer's disease.

摘要: Abstract Starting from nature as original source, new potential agents with pleiotropic activities have been synthesized and evaluated neuroprotective agents. In this work, novel nature-based hybrids, combining antioxidant motifs rivastigmine, designed synthesized. The biological results revealed that the compounds inhibit both AChE BuChE. particular, lipoic acid hybrids LA1, LA2, LA3 resulted to be most potent inhibitors of BuChE showing IC50 values ranging 340 378 nM. Analogously, all were able self β-amyloid1-42 aggregation. gallic hybrid GA2 well 2-chromonecarboxylic CA1 CA2 prevented self-mediated Aβ aggregation percentages inhibition 53% 59%. Finally, some them also show effects against glutamate-induced cell death low toxicity in HT22 cells.