Restriction of rapid eye movement sleep during adolescence increases energy gain and metabolic efficiency in young adult rats.

摘要: What is the central question of this study? Sleep curtailment in infancy and adolescence may lead to long-term risk for obesity, but mechanisms involved have not yet been determined. This study examined immediate metabolic effects produced by sleep restriction young rats. main finding its importance? Prolonged reduced weight gain (body fat stores) animals. After prolonged recovery, sleep-restricted rats tended save more energy store fat, possibly owing increased gross food efficiency. could be first step understand association. associated with obesity changes adults children. The aim present was evaluate alterations pubertal male Male Wistar (28 days old) were allocated a control (CTL) group or (SR) group. accomplished single platform technique 18 h per day 21 days. These groups subdivided into following four time points assessment: 1, 2 4 months recovery. Body intake monitored throughout experiment. At end each period, blood collected profiling, carcasses processed measurement body composition balance. During period restriction, SR animals consumed less home cages. also displayed lower weight, triglycerides glucose levels than CTL month despite eating as much rats, showed greater gain, efficiency decreased expenditure. second fourth no longer different, except efficiency, which remained higher In conclusion, affected animals, reduction stores. Two sufficient recover deficit reveal that fat.