RNA Aptamer Technology

摘要: Article history Aptamers are single stranded nucleic acids that specifically recognize and bind tightly to their cognate targets due stable three dimensional structures. Nucleic acid aptamers have been developed for various applications, including diagnostics, molecular imaging biomarker discovery along with target validation, therapeutics, drug delivery. Since its in the early 1990s, aptamer technology has progressed tremendously. Automated selection procedures now allow rapid identification of DNA RNA sequences can a broad range extra intracellular proteins nanomolar affinities high specificities. The unique binding properties acids, which amenable modifications, make perfectly suitable different areas biotechnology. represent an emerging class pharmaceuticals great potential targeted cancer diagnostics therapy. Several cell-surface antigens affinity specificity described. However, clinical yet be realized demand diagnostic assays assist management existing diseases is increasing, could potentially fulfill recognition needs those assays. Compared bellwether antibody technology, research still infancy, but it progressing at fast pace. may near future form aptamer-based products market. In such products, play key role either conjunction with, or place antibodies. It also likely formats change according need better harness features. This review summarizes as valuable tools discovery, even therapeutic approaches.