Heterogeneous gland size in sporadic multiple gland parathyroid hyperplasia.

摘要: Abstract Background: The success rate for bilateral exploration in patients with primary hyperparathyroidism approaches 95%. Multiglandular parathyroid hyperplasia accounts approximately 10% to 30% of hyperparathyroidism. incidence recurrent or persistent is highest familial forms the disease, which multiglandular disease more common; this may be due asymmetric enlargement glands. Because improvements tumor-imaging capability, some surgeons are now advocating unilateral hyperparathyroidism, but there limited experience concerning how often these imaging methods fail. Study Design: outcomes 7 who had sporadic multigland were reviewed. We gathered demographic data and laboratory values reviewed radiologic tests, surgical findings, pathologic postoperative followup. Results: All underwent preoperative localization ultrasonography technetium/sestamibi scans. sensitivity two tests dominantly enlarged gland was 100% both, dropped 0% 5%, respectively, all other CT MRI dominant tumor 67% (2 3) 50% (1 2), respectively. Six subtotal (312 gland) parathyroidectomy. mean volume glands 1.51 ± 5.89 cm 3 compared a 5.66 11.4 0.123 0.1 nondominant hyperplastic There large amount variability between volumes as demonstrated by SDs from mean. Conclusions: marked heterogeneity size hyperplasia, similar that found multiple endocrine neoplasia type I. This result failure recognize if neck performed. Intraoperative hormone assay prove an important adjunct population have unsuspected disease.