Transcription Factors Stat5a/b and Stat3 in Prostate Cancer Growth and Metastases
作者： Tuomas K. Mirtti , Pooja Talati , Marja T. Nevalainen
DOI: 10.1007/978-94-007-2558-4_10
关键词:
摘要: The majority of prostate cancer fatalities are caused by development castration-resistant growth and metastatic spread the primary tumor. There currently no effective treatments for advanced therefore it is imperative to develop more therapies cancer. Transcription factors Stat5a/b Stat3 both represent potential therapeutic target proteins Stat5 major signal transducer downstream Prolactin (Prl) receptors in human cells, while known as key mediator IL-6 effects. constitutively active clinical cancers high histological grades distant metastases. In addition, functionally interact with androgen receptor cells. While bind same DNA consensus sequence, regulates largely different genes from those that regulated Importantly, has a preferential role over promotion cell viability tumor growth. At time, stimulate behavior cells vitro vivo. Janus kinase family (Jaks) activators Stat proteins. Inhibitors Jak2 would transcription theoretically provide control well potential.
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