Batcho–Leimgruber indole synthesis

作者: Jie Jack Li

DOI: 10.1007/978-3-319-03979-4_17

关键词:

摘要: Condensation of o-nitrotoluene derivatives with formamide acetals, followed by reduction the trans-β-dimethylamino-2-nitrostyrene to furnish indole derivatives.

参考文章(18)
Richard J. Sundberg, The chemistry of indoles ,(1970)
Hannes A. Braun, Andrea Zall, Manfred Brockhaus, Marco Schütz, Reinhard Meusinger, Boris Schmidt, Aspartic protease inhibitors via C1-homologation of peptidic aldehydes and studies on reduced amide isosteres Tetrahedron Letters. ,vol. 48, pp. 7990- 7993 ,(2007) , 10.1016/J.TETLET.2007.09.047
Alan P. Kozikowski, Hitoshi Ishida, Yon-Yih Chen, New synthesis and some selected reactions of the potential ergot alkaloid precursor indole-4-carboxaldehyde Journal of Organic Chemistry. ,vol. 45, pp. 3350- 3352 ,(1980) , 10.1021/JO01304A043
R. D. CLARK, D. B. REPKE, THE LEIMGRUBER-BATCHO INDOLE SYNTHESIS Heterocycles. ,vol. 22, pp. 195- 221 ,(1984) , 10.1002/CHIN.198428368
Robin D. Clark, David B. Repke, Some observations on the formation of 1‐hydroxyindoles in the leimgruber‐batcho indole synthesis Journal of Heterocyclic Chemistry. ,vol. 22, pp. 121- 125 ,(1985) , 10.1002/JHET.5570220130
David B. Repke, Wilfred J. Ferguson, Psilocin analogs. III. Synthesis of 5-methoxy- and 5-hydroxy-1,2,3,4-tetrahydro-9H-pyrido[3,4-b]indoles Journal of Heterocyclic Chemistry. ,vol. 19, pp. 845- 848 ,(1982) , 10.1002/JHET.5570190428
R.F. Abdulla, R.S. Brinkmeyer, The chemistry of formamide acetals Tetrahedron. ,vol. 35, pp. 1675- 1735 ,(1979) , 10.1016/0040-4020(79)88001-1
Mikel P. Moyer, John F. Shiurba, Henry Rapoport, Metal-halogen exchange of bromoindoles. A route to substituted indoles Journal of Organic Chemistry. ,vol. 51, pp. 5106- 5110 ,(1986) , 10.1021/JO00376A010
Paul L. Feldman, Henry Rapoport, Convenient Synthesis of 6-Methoxyindole and 6-Methoxytryptophyl Bromide Synthesis. ,vol. 1986, pp. 735- 737 ,(1986) , 10.1055/S-1986-31759
Marie-Pierre Lézé, Anja Palusczak, Rolf W. Hartmann, Marc Le Borgne, Synthesis of 6- or 4-functionalized indoles via a reductive cyclization approach and evaluation as aromatase inhibitors Bioorganic & Medicinal Chemistry Letters. ,vol. 18, pp. 4713- 4715 ,(2008) , 10.1016/J.BMCL.2008.06.094