Adult hippocampal neurogenesis in the pathogenesis of addiction and dual diagnosis disorders.

摘要: Background As knowledge deepens about how new neurons are born, differentiate, and wire into the adult mammalian brain, growing evidence depicts hippocampal neurogenesis as a special form of neuroplasticity that may be impaired across psychiatric disorders. This review provides an integrated-evidence based framework describing neurogenic basis for addictions addiction vulnerability in mental illness. Methods Basic studies conducted over last decade examining effects addictive drugs on impact activity behavior were compiled integrated with relevant neurocomputational human studies. Results While suppression proliferation appears to universal property drugs, pathophysiology involves neuroadaptative processes within frontal-cortical-striatal motivation circuits hippocampus regulates via direct projections. States suppressed simultaneously underlie cognitive symptoms, but also confer or signify dysfunction heightens illness dual diagnosis Conclusions Research pharmacological, behavioral experiential strategies enhance adaptive regulation holds potential advancing preventative integrative treatment