作者: Tadamichi Denda , Tomonori Ambo , Atsushi Ohtsu , Yasuhide Yamada , Kuniaki Shirao
DOI: 10.1007/S00280-003-0604-1
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摘要: Purpose Experimental studies have shown that mitomycin C (MMC) acts synergistically with irinotecan. We evaluated the antitumor activity and toxicity of a combination irinotecan MMC in patients metastatic colorectal cancer resistant to fluoropyrimidines.