Breaking Speed and Sensitivity Limits

作者: Bahram Jalali , Patrick Soon-Shiong , Keisuke Goda

DOI: 10.1002/OPPH.201190095

关键词:

摘要: High-throughput imaging is needed to identify rare diseased cells among a large population of healthy cells. When combined with microfluidics, this labelfree cell identification method can revolutionize pathology, cancer screening, and potentially even stem therapy. Featuring optical image streaming amplification, new approach overcomes the technological fundamental limits classic sensor technology may represent solution.

参考文章(23)
James V. Watson, Introduction to Flow Cytometry ,(2008)
K. Goda, K. K. Tsia, B. Jalali, Serial time-encoded amplified imaging for real-time observation of fast dynamic phenomena Nature. ,vol. 458, pp. 1145- 1149 ,(2009) , 10.1038/NATURE07980
Michalina Gora, Karol Karnowski, Maciej Szkulmowski, Bartlomiej J. Kaluzny, Robert Huber, Andrzej Kowalczyk, Maciej Wojtkowski, Ultra high-speed swept source OCT imaging of the anterior segment of human eye at 200 kHz with adjustable imaging range Optics Express. ,vol. 17, pp. 14880- 14894 ,(2009) , 10.1364/OE.17.014880
Jason Chou, Ozdal Boyraz, Daniel Solli, Bahram Jalali, Femtosecond real-time single-shot digitizer Applied Physics Letters. ,vol. 91, pp. 161105- ,(2007) , 10.1063/1.2799741
P.V. Kelkar, F. Coppinger, A.S. Bhushan, B. Jalali, Time-domain optical sensing Electronics Letters. ,vol. 35, pp. 1661- 1662 ,(1999) , 10.1049/EL:19991116
Keisuke Goda, Daniel R. Solli, Bahram Jalali, Real-time optical reflectometry enabled by amplified dispersive Fourier transformation Applied Physics Letters. ,vol. 93, pp. 031106- ,(2008) , 10.1063/1.2963974
D. Di Carlo, D. Irimia, R. G. Tompkins, M. Toner, Continuous inertial focusing, ordering, and separation of particles in microchannels Proceedings of the National Academy of Sciences of the United States of America. ,vol. 104, pp. 18892- 18897 ,(2007) , 10.1073/PNAS.0704958104
Desmond C. Adler, Yu Chen, Robert Huber, Joseph Schmitt, James Connolly, James G. Fujimoto, Three-dimensional endomicroscopy using optical coherence tomography Nature Photonics. ,vol. 1, pp. 709- 716 ,(2007) , 10.1038/NPHOTON.2007.228