Epidemiology of Invasive Early-Onset and Late-Onset Group B Streptococcal Disease in the United States, 2006 to 2015: Multistate Laboratory and Population-Based Surveillance.

摘要: Importance Invasive disease owing to group BStreptococcus(GBS) remains an important cause of illness and death among infants younger than 90 days in the United States, despite declines early-onset (EOD; with onset at 0-6 life) that are attributed intrapartum antibiotic prophylaxis (IAP). Maternal vaccines prevent infant GBS currently under development. Objective To describe incidence rates, case characteristics, antimicrobial resistance, serotype distribution EOD late-onset (LOD; 7-89 States from 2006 2015 inform IAP guidelines vaccine Design, Setting, Participants This study used active population-based laboratory-based surveillance for invasive conducted through Active Bacterial Core selected counties 10 states across States. Residents areas who were had included. Data analyzed December 2017 April 2018. Exposures Group BStreptococcusisolated a normally sterile site. Main Outcomes Measures Early-onset LOD rates associated serotypes resistance. Results The program identified 1277 cases 1387 LOD. From 2015, declined significantly 0.37 0.23 per 1000 live births (P  Conclusions Relevance US now higher rates. Combined addressing implementation gaps, effective covering most common might further reduce help LOD, which there is no current public health intervention.