Carbonic anhydrase: mechanism, regulation, links to disease, and industrial applications

摘要: Preface. Part I Introduction. 1 Overview of the Carbonic Anhydrase Field. II Anhydrases: Ancient but Relevant. Physiological Functions Alpha Class Anhydrases. 3 Catalytic Mechanism alpha-Class CO2 Hydration and Proton Transfer. 4 Structure b-Carbonic 5 Prokaryotic Anhydrases Earth's Environment. 6 Carboxysomal 7 their Interplay with Acid/base-coupled Membrane Transporters. 8 Related Proteins: Molecular Biology Evolution. 9 Associated IV (CA IV): A Personal Historical Perspective. 10 Expression in Kidney Renal Cancer: Implications for Diagnosis Treatment. 11 IX: Regulation Role Cancer. 12 IX as an Imaging Therapeutic Target Tumors Metastases. 13 (CAIX) a Mediator Hypoxia-induced Stress Response Cancer Cells. 14 Brain pH Control Neruronal Excitability. 15 Inhibitors: Drug Design. 16 Natural Products that Inhibit 17 Glaucoma Application Inhibitors. 18 Inhibitors High Altitude Illnesses. 19 Thermal-Stable Structural Overview. 20 Industrial Applications. Index.