CD36‐triggered cell invasion and persistent tissue colonization by tumor microvesicles during metastasis

摘要: Tumor microvesicles are a peculiar type of extracellular vesicles that circulate in the blood patients with metastatic cancer. The itineraries and immune cell interactions tumor during intravascular extravascular stages metastasis largely unknown. We found lipid receptor CD36 is major mediator engulfment pancreatic by myeloid cells vitro critically samples circulating resident liver macrophages mice vivo. Direct nanoscopic imaging individual shows rapidly decay whereby their cargo targeted concomitantly to plasma membrane cytoplasm excluding lysosomal compartments. also promotes internalization (nontumor) microvesicles, which involves endolysosomal pathways. A portion microcirculation traverses vessel wall CD36-dependent way. Extravasated colonize distinct perivascular Ly6C- for at least 2 wk. Thus, increasingly integrated into CD36-induced premetastatic clusters enhance development metastasis. Hence, promotion associated CD36-regulated invasion extravasation persistent infiltration specific tissue microvesicle cargo.-Pfeiler, S., Thakur, M., Grunauer, P., Megens, R. T. A., Joshi, U., Coletti, R., Samara, V., Muller-Stoy, G., Ishikawa-Ankerhold, H., Stark, K., Klingl, Frohlich, T., Arnold, G. J., Wormann, Bruns, C. Algul, Weber, C., Massberg, Engelmann, B. CD36-triggered colonization