SARS-CoV-2 ORF6 disturbs nucleocytoplasmic trafficking to advance the viral replication
作者： Kohji Moriishi , Yoichiro Kamatani , Yoshihiro Yoneda , Toru Okamoto , Tomohisa Tanaka
DOI: 10.1101/2021.02.24.432656
关键词:
摘要: Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is the virus responsible for disease 2019 pandemic. ORF6 known to antagonize interferon signaling by inhibiting nuclear translocation of STAT1. Here we show that acts as a virulence factor through two distinct strategies. First, directly interacts with STAT1 in an IFN-independent manner inhibit its translocation. Second, binds importin 1, which transport encoded KPNA2, leading significant suppression 1-mediated transport. Furthermore, found KPNA2 knockout enhances viral replication, suggesting 1 suppresses propagation. Additionally, analyses gene expression data revealed levels decreased significantly lungs older individuals. Taken together, SARS-CoV-2 disrupts nucleocytoplasmic trafficking accelerate resulting progression, especially
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