Effect of transport conditions on the stability of biochemical markers in blood.

摘要: We examined the stability of lipids, carotenoids, alpha-tocopherol, and endogenous hormones in plasma prepared from whole blood that had been mailed to a central location for processing. Initially, simulate transport conditions, whole-blood samples were stored laboratory, either at room temperature or cooled, up 72 h before In latter samples, lipid concentrations changed 1.4% per day, carotenoids -5.5%, 9.5%. second study, analyte cooled via overnight courier compared with those immediately separated, frozen, courier. Concentrations cholesterol, high-density lipoprotein subfraction 3, apolipoprotein B, retinol stable. Overall, each marker except estradiol, between-person variation was least twice within-person variation. third 340 micrograms DNA recovered 30 mL cool-shipped blood. Our results indicate shipping by is feasible assay several biochemical markers interest epidemiological research.