作者: Liang Yuan , Nongjian Tao , Wei Wang
DOI: 10.1146/ANNUREV-ANCHEM-061516-045150
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摘要: Electrochemical impedance spectroscopy (EIS) measures the frequency spectrum of an electrochemical interface to resist alternating current. This method allows label-free and noninvasive studies on interfacial adsorption molecular interactions has applications in biosensing drug screening. Although powerful, traditional EIS lacks spatial resolution or imaging capability, hindering study heterogeneous processes electrodes. We have recently developed a plasmonics-based technique image local with submicron submillisecond temporal resolution. In this review, we provide systematic description theory, instrumentation, data analysis technique. To illustrate its present future applications, further describe several selected samples analyzed method, including protein microarrays, two-dimensional materials, single cells. conclude by summarizing technique's unique features discussing remaining challenges new directions application.