Intradermal microdialysis of hypertonic saline attenuates cutaneous vasodilatation in response to local heating.

摘要: We tested the hypothesis that microdialysis of hypertonic saline would attenuate skin blood flow response to local heating. Seventeen healthy subjects (23 ± 1 years old) were studied. In one group (n= 9), four fibres placed in forearm and infused with following: (1) Ringer solution; (2) normal (0.9% NaCl); (3) (3% (4) 10 mm l-NAME. A second 8) was saline; +l-NAME; +l-NAME. Red cell flux measured via laser Doppler flowmetry during heating 42°C. Site-specific maximal vasodilatation determined by infusing 28 sodium nitroprusside while heated 43°C. Data expressed as percentage cutaneous vascular conductance (%CVCmax). The at solution sites did not differ 9; initial peak solution, 69 6 versus saline, 66 2%CVCmax; plateau 89 4 5%CVCmax). Hypertonic reduced 2 54 4%CVCmax; P < 0.05) (normal 5 78 compared saline. Plateau %CVCmax attenuated a similar value +l-NAME 8; +l-NAME, 39 nitric oxide contribution (plateau %CVCmax–l-NAME %CVCmax) lower site 55 35 4; 0.01). These data suggest an effect salt on heating, which may be mediated through decreased production and/or availability oxide.