Effects of three calcium channel antagonists (amlodipine, diltiazem and verapamil) on the protective action of lamotrigine in the mouse maximal electroshock-induced seizure model.
作者： Jarogniew J Luszczki , Kinga K Borowicz , Michał K Trojnar , Stanisław J Czuczwar , Anna Zadrozniak
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摘要: The aim of this study was to assess the effect three calcium channel antagonists (amlodipine, diltiazem and verapamil) on anticonvulsant action lamotrigine (a second generation antiepileptic drug) against maximal electroshock-induced seizures in mice. Results indicated that all when administered alone [amlodipine (up 20 mg/kg, ip), 10 ip) verapamil ip)], did not significantly affect threshold for electroconvulsions However, amlodipine at a non-protective dose ip enhanced activity seizure test mice by reducing its ED(50) value from 6.33 2.87 mg/kg (p < 0.05). In contrast, lower doses 5 ip, (at up had no significant impact antiseizure conclusion, one can ascertain favorable combination with deserves more attention clinical viewpoint because lamotrigine.
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