Do American oncologists know how to use prognostic variables for patients with newly diagnosed primary breast cancer

作者: C L Loprinzi , P M Ravdin , M de Laurentiis , P Novotny

DOI: 10.1200/JCO.1994.12.7.1422

关键词:

摘要: PURPOSEThis project was designed to investigate how American medical oncologists actually use prognostic information treat primary breast cancer patients, and study their difficulties in combining complex sometimes contradictory information.METHODSA simple 2-page questionnaire faxed May June 1993 a sample of who were members the Society Clinical Oncology (ASCO).RESULTSWhen presented with case histories patients newly diagnosed invasive asked assess prognosis on basis tumor size, number involved axillary nodes, patient age, estrogen receptor level, progesterone there wide divergence opinions about probability disease-free survival at 10 years (both for cases which received no adjuvant therapy those did receive such therapy). The additional data (such as S-phase, histologic nuclear grading...

参考文章(15)
P P Rosen, S Groshen, P E Saigo, D W Kinne, S Hellman, Pathological prognostic factors in stage I (T1N0M0) and stage II (T1N1M0) breast carcinoma: a study of 644 patients with median follow-up of 18 years. Journal of Clinical Oncology. ,vol. 7, pp. 1239- 1251 ,(1989) , 10.1200/JCO.1989.7.9.1239
R. Elledge, S. A. W. Fuqua, R. W. Brown, G. C. Chamness, C. K. Osborne, W. L. McGuire, D. C. Allred, G. M. Clark, Association of p53 Protein Expression With Tumor Cell Proliferation Rate and Clinical Outcome in Node-Negative Breast Cancer Journal of the National Cancer Institute. ,vol. 85, pp. 200- 206 ,(1993) , 10.1093/JNCI/85.3.200
Hans-Olov Adami, Birgitta Malker, Lars Holmberg, Ingemar Persson, Betty Stone, The relation between survival and age at diagnosis in breast cancer. The New England Journal of Medicine. ,vol. 315, pp. 559- 563 ,(1986) , 10.1056/NEJM198608283150906
Marcus H. Galea, Roger W. Blamey, Christopher E. Elston, Ian O. Ellis, The Nottingham Prognostic Index in primary breast cancer. Breast Cancer Research and Treatment. ,vol. 22, pp. 207- 219 ,(1992) , 10.1007/BF01840834
Bernard Fisher, Nurten Gunduz, Joseph Costantino, Edwin R. Fisher, Carol Redmond, Eleftherios P. Mamounas, Richard Siderits, DNA flow cytometric analysis of primary operable breast cancer. Relation of ploidy and S-phase fraction to outcome of patients in NSABP B-04. Cancer. ,vol. 68, pp. 1465- 1475 ,(1991) , 10.1002/1097-0142(19911001)68:7<1465::AID-CNCR2820680702>3.0.CO;2-I
J A Foekens, W L van Putten, H Portengen, H Y de Koning, B Thirion, J Alexieva-Figusch, J G Klijn, Prognostic value of PS2 and cathepsin D in 710 human primary breast tumors: multivariate analysis. Journal of Clinical Oncology. ,vol. 11, pp. 899- 908 ,(1993) , 10.1200/JCO.1993.11.5.899
Coffee and pancreatic cancer (Chapter 2) The New England Journal of Medicine. ,vol. 315, pp. 587- 589 ,(1986) , 10.1056/NEJM198608283150918