Bacteriophages of Klebsiella spp., their diversity and potential therapeutic uses.
作者： Lesley Hoyles , Warren P Herridge , Thomas C Brook , Preetha Shibu , Jessica O'Shea
DOI: 10.1099/JMM.0.001141
关键词:
摘要: Klebsiella spp. are commensals of the human microbiota, and a leading cause opportunistic nosocomial infections. The incidence multidrug resistant (MDR) strains pneumoniae causing serious infections is increasing, oxytoca an emerging pathogen. Alternative strategies to tackle caused by these bacteria required as become last-resort antibiotics such colistin. Bacteriophages (phages) viruses that can infect kill bacteria. They their gene products now being considered alternatives or adjuncts antimicrobial therapies. Several in vitro vivo studies have shown potential for lytic phages combat MDR K. Ready access cheap sequencing technologies has led large increase number genomes available Klebsiella-infecting phages, with heterogeneous at whole-genome level. This review summarizes our current knowledge on highlights technological biological issues relevant development phage-based therapies targeting
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