The role of 20-HETE in androgen-mediated hypertension.

摘要: Androgen plays an important role in blood pressure regulation. Epidemiological studies have shown that men a higher prevalence for developing hypertension than aged-matched, premenopausal women. Interestingly, postmenopausal women and with polycystic ovary syndrome, both of which increased endogenous androgen production, elevated risks suggesting may contribute to its development. Studies from our laboratory others provided substantial evidence 20-hydroxyeicosatetraenoic acid (20-HETE) mediates the seen rodents treated androgen. 20-HETE is cytochrome P450 (CYP)-derived ω-hydroxylated metabolite arachidonic acid. complex In kidney tubules, decreases by promoting natriuresis, while microvasculature it has pressor effect. microcirculation, participates regulation vascular tone sensitizing smooth muscle cells constrictor stimuli contributes myogenic, mitogenic angiogenic responses. addition, acts on endothelium promote endothelial dysfunction activation. Recently, we demonstrated induces ACE thus setting forth potential feed forward mechanism through activation Renin-Angiotensin-Aldosterone-System. this review, will discuss pro-hypertensive effects androgen-induced hypertension.