Antimicrobial activities of the bromophenols from the red alga Odonthalia corymbifera and some synthetic derivatives.

摘要: Abstract A series of bromophenols was obtained by isolation from red alga Odonthalia corymbifera and reactions bis(hydroxyphenyl)methanes with bromine. New including 3,3′,5,5′-tetrabromo-2,2′,4,4′-tetrahydroxydiphenylmethane ( 10 ), a regioisomer the potent antimicrobial natural product, together known derivatives were synthesized in high yield. All isolated compounds tested for activity against Gram-negative, Gram-positive bacteria fungi. The preliminary structure–activity relationship, to elucidate essential structure requirements activity, has been described. Among products 2,2′,3,3′-tetrabromo-4,4′,5,5′-tetrahydroxydiphenylmethane 4 ) found be most active derivative Candida albicans , Aspergillus fumigatus Trichophyton rubrum mentagrophytes . synthetic 3,3′-dibromo-6,6′-dihydroxydiphenylmethane 13 3,3′,5,5′-tetrabromo-6,6′-dihydroxydiphenylmethane 14 showed antibacterial effect Staphylococcus aureus Bacillus subtilis Micrococcus luteus Proteus vulgaris Salmonella typhimurium