Pkm2 modulators and methods for their use
作者： Jason Marc Foulks , David Lee Vollmer , Koc-Kan Ho , Jihua Liu , Yong Xu
DOI:
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摘要: Compounds having activity as PKM2 activators are disclosed. The compounds have the following structure (I): including stereoisomers, tautomers, pharmaceutically acceptable salts and prodrugs thereof, wherein R1, R2, R3, R4, R5 R6 defined herein. Methods associated with preparation use of such compounds, well pharmaceutical compositions comprising also
lens.org参考文章(98)
Hans Bundgaard, Design of prodrugs Elsevier , Sole distributors for the USA and Canada, Elsevier Science Pub. Co.. ,(1985)
Francesco G. Salituro, Jeffrey O. Saunders, Shunqi Yan, Novel n-(4-(azetidine-1-carbonyl) phenyl) - (hetero-) arylsulfonamide derivatives as pyruvate kinase m2 (pmk2) modulators ,(2011)
K. Ashizawa, M.C. Willingham, C.M. Liang, S.Y. Cheng, In vivo regulation of monomer-tetramer conversion of pyruvate kinase subtype M2 by glucose is mediated via fructose 1,6-bisphosphate. Journal of Biological Chemistry. ,vol. 266, pp. 16842- 16846 ,(1991) , 10.1016/S0021-9258(18)55378-3
Sabine Schlyer, Alexander Heim-Riether, Shuang Liang, Fused heteroaryl diamide compounds useful as mmp-13 inhibitors ,(2009)
David B. Ring, Hermann Oppermann, James S. Huston, L. L. Houston, DNA encoding biosynthetic binding protein for cancer marker ,(1994)
Francesco G. Salituro, Janeta Popovici-Muller, Jeffrey O. Saunders, Shunqi Yan, Jeremey M. Travins, Therapeutically active compositions and their methods of use ,(2016)
Avihai Yacovan, Efrat Ben-Zeev, Sima Mirilashvili, Rachel Ozeri, Nili Schutz, Osnat Kashtan, Alex Aizikovich, Tzofit Kehat, Alina Shitrit, Vered Behar, Oren M. Becker, Daniel Sherman, Sulfonamides for the modulation of pkm2 ,(2011)
David Thomas Dudley, Craig Mason Flory, Alan Robert Saltiel, Treatment of arthritis with mek inhibitors ,(1999)
Ralph Pelton Robinson, N-hydroxy-beta-sulfonyl-propionamide derivatives and their use as inhibitors of matrix metalloproteinases ,(1998)
Rodney Caughren Schnur, Lee Daniel Arnold, Alkynl and azido-substituted 4-anilinoquinazolines ,(2008)