Defining neurotoxicity in a decision-making context.

摘要: Neurotoxicity is one of several noncancer endpoints used by regulatory agencies in risk assessment. At the US EPA, neurotoxicity defined as an adverse change structure and/or function central peripheral nervous system measured at neurochemical, behavioral, neurophysiological or anatomical levels. Adverse effects include alterations that diminish organism's ability to survive, reproduce adapt environment. Generally, a weight-of-evidence approach evaluate observed effects. There is, for example, high level concern persistent changes system, while transient must be evaluated using further criteria. Compensatory resulting from cell death might represent activation repair capacity and, since this could decrease future potential adaptability, reversibility viewed with concern. In general, equal weight given chemicals directly indirectly affect system. Finally, on compared those other organ systems help rule out non-specific neurobiological measures.