Effects of alpha-linked galactooligosaccharide on adjuvant-induced arthritis in Wistar rats and type II collagen-induced arthritis in DBA/1J mice.

摘要: alpha-Linked galactooligosaccharide (alpha-GOS) has been reported to change the composition of enteric microflora. In present study, antiarthritic effect alpha-GOS was evaluated by employing adjuvant-induced arthritis (AIA) in Wistar rats and type II collagen-induced (CIA) DBA/1J mice. The animals were given orally. This substance had beneficial effects on both clinical signs, such as erythema swelling limbs, histopathological findings hind paw joints a dose-dependent manner. reduced plasma nitrite/nitrate (NOx) level with AIA. cell culture system peritoneal macrophages from AIA, enhanced interleukin-1 production without lipopolysaccharide stimulation manner, suggesting that stimulates through modulation Since modulates microflora, could be partly attributable its immunomodulating activity. Thus, is potential functional food for treatment human rheumatoid arthritis.