Myelodysplastic/Myeloproliferative Disorder Overlap Syndrome: How Should it be Approached?

摘要: Abstract The chronic myeloid disorders are typically divided into myelodysplastic syndromes (MDS) and myeloproliferative (MPD). However, there a group of with overlapping features MDS MPD. World Health Organization has recently reclassified hematologic included category MDS/MPD overlap syndromes, which include myelomonocytic leukemia, atypical myelogenous juvenile unclassifiable, includes the provisional entity refractory anemia ringed sideroblasts associated marked thrombocytosis (RARS-T). These latter 4 remain largely enigmatic in their pathogenesis, have poor prognosis, limited therapeutic options. JAK2 -V617F mutation been discovered large majority patients RARS-T might future implications. approach to management these relies on extrapolation from other MPD that similar syndromes.