Estimated 24 h Urinary Sodium-to-Potassium Ratio Is Related to Renal Function Decline: A 6-Year Cohort Study of Japanese Urban Residents.

摘要: The effect of the sodium-to-potassium ratio (Na/K) on renal function within clinically normal range are limited. We investigated effects an estimated 24 h urinary Na/K (e24hUNa/K) a 6-year decline among 927 urban Japanese community dwellers with no history cardiovascular diseases and medication for hypertension, diabetes, or dyslipidemia. partitioned subjects into quartiles according to e24hUNa/K. glomerular filtration rate (eGFR) was calculated using chronic kidney disease epidemiology collaboration (CKD/EPI) formula defined as absolute value at above third quartile eGFR rate. A multivariable logistic regression model used estimation. Compared first e24hUNa/K, multivariable-adjusted odds ratios (ORs) in second, third, fourth were 0.96 (95% confidence interval: 0.61-1.51), 1.06 (0.67-1.66), 1.65 (1.06-2.57), respectively. These results similar when simple spot urine place Apparently healthy residents almost mean baseline high e24hUNa/K had increased risk future function. Reducing may be important prevention its early stage.