Preoperative radiotherapy combined with total mesorectal excision for resectable rectal cancer: 12-year follow-up of the multicentre, randomised controlled TME trial
作者： Willem van Gijn , Corrie AM Marijnen , Iris D Nagtegaal , Elma Meershoek-Klein Kranenbarg , Hein Putter
DOI: 10.1016/S1470-2045(11)70097-3
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摘要: Background The TME trial investigated the value of preoperative short-term radiotherapy in combination with total mesorectal excision (TME). Long-term results are reported after a median follow-up of 12 years. Methods Between Jan 12, 1996, and Dec 31, 1999, 1861 patients with resectable rectal cancer without evidence of distant disease were randomly assigned to TME preceded by 5× 5 Gy radiotherapy or TME alone (ratio 1: 1). Randomisation was based on permuted blocks of six with stratification according to centre …
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