TXN, a Xanthohumol Derivative, Significantly Attenuates High-Fat Diet Induced Hepatic Steatosis In Vivo by Antagonizing PPARγ

作者: Gerd Bobe , Claudia S. Maier , Cristobal L. Miranda , Jan F. Stevens , Malcolm B. Lowry

DOI: 10.1101/2021.01.11.426043

关键词:

摘要: … TXN bind in the PPARγ ligand-binding domain pocket. Our findings are consistent with XN and TXN … results suggest TXN treatment inhibits the PPARγ pathway – a key pathway involved …

参考文章(83)
Tagle Arrospide M, [Non-alcoholic fatty liver]. Revista de gastroenterologia del Peru : organo oficial de la Sociedad de Gastroenterologia del Peru. ,vol. 23, pp. 49- 57 ,(2003)
Y Zhu, K Alvares, Q Huang, M S Rao, J K Reddy, Cloning of a new member of the peroxisome proliferator-activated receptor gene family from mouse liver. Journal of Biological Chemistry. ,vol. 268, pp. 26817- 26820 ,(1993) , 10.1016/S0021-9258(19)74184-2
Etsuko Hashimoto, Makiko Taniai, Katsutoshi Tokushige, Characteristics and diagnosis of NAFLD/NASH Journal of Gastroenterology and Hepatology. ,vol. 28, pp. 64- 70 ,(2013) , 10.1111/JGH.12271
Shingo Miyata, Jun Inoue, Makoto Shimizu, Ryuichiro Sato, Xanthohumol Improves Diet-induced Obesity and Fatty Liver by Suppressing Sterol Regulatory Element-binding Protein (SREBP) Activation. Journal of Biological Chemistry. ,vol. 290, pp. 20565- 20579 ,(2015) , 10.1074/JBC.M115.656975
Lianne van Beek, Jan B. van Klinken, Amanda C. M. Pronk, Andrea D. van Dam, Eline Dirven, Patrick C. N. Rensen, Frits Koning, Ko Willems van Dijk, Vanessa van Harmelen, The limited storage capacity of gonadal adipose tissue directs the development of metabolic disorders in male C57Bl/6J mice. Diabetologia. ,vol. 58, pp. 1601- 1609 ,(2015) , 10.1007/S00125-015-3594-8
Yong-tao Li, Li Li, Jing Chen, Tian-cen Hu, Jin Huang, Yue-wei Guo, Hua-liang Jiang, Xu Shen, 7-Chloroarctinone-b as a new selective PPARγ antagonist potently blocks adipocyte differentiation Acta Pharmacologica Sinica. ,vol. 30, pp. 1351- 1358 ,(2009) , 10.1038/APS.2009.113
Zhenwei Gong, Cheng Huang, Xiaoyan Sheng, Yuebo Zhang, Qunyi Li, Ming-Wei Wang, Linling Peng, Ying Qin Zang, The Role of Tanshinone IIA in the Treatment of Obesity through Peroxisome Proliferator-Activated Receptor γ Antagonism Endocrinology. ,vol. 150, pp. 104- 113 ,(2009) , 10.1210/EN.2008-0322
Jay S. Kirkwood, LeeCole L. Legette, Cristobal L. Miranda, Yuan Jiang, Jan F. Stevens, A Metabolomics-driven Elucidation of the Anti-obesity Mechanisms of Xanthohumol Journal of Biological Chemistry. ,vol. 288, pp. 19000- 19013 ,(2013) , 10.1074/JBC.M112.445452