A primate-specific short GluN2A-NMDA receptor isoform is expressed in the human brain.

摘要: Glutamate receptors of the N-methyl-D-aspartate (NMDA) family are coincident detectors pre- and postsynaptic activity, allowing Ca2+ influx into neurons. These properties central to neurological disease mechanisms proposed be basis associative learning memory. In addition well-characterised canonical GluN2A NMDAR isoform, large-scale open reading frames in human tissues had suggested expression a primate-specific short isoform referred as GluN2A-S. Here, we confirm both transcripts primate but not rodent brain tissue, show that they translated two corresponding proteins present brain. Furthermore, demonstrate recombinant GluN2A-S co-assembles with obligatory subunit GluN1 form functional NMDA receptors. findings suggest more complex repertoire than previously thought.