Computationally Modeling Lipid Metabolism and Aging: A Mini-review.
作者： Mark T. Mc Auley , Kathleen M. Mooney
DOI: 10.1016/J.CSBJ.2014.11.006
关键词:
摘要: article i nfo Available online 15 November 2014 One of the greatest challenges in biology is to improve understanding mechanisms which underpin aging and how these affect health. The need better understand amplified by demographic changes, have caused a gradual increase global population older people. Aging western populations resulted rise prevalence age-related pathologies. Of diseases, cardiovascular disease most common underlying condition dysregulation lipid metabolism due im- pinges significantlyoncardiovascularhealth.However,themultifacetednatureoflipidmetabolismandthecom- plexities its interaction with make it challenging conventional means. To address this challenge computational modeling, key component systems paradigm being used study dynamics metabolism. This mini-review briefly outlinesthe regulators metabolism, their dys- regulation, modeling gain an increased insight into system. © . Mc Auley Mooney. Published Elsevier B.V. on behalf Research Network Computational Structural Biotechnology. open access under CC BY 3.0 license
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