Elevated nitric oxide production in rheumatoid arthritis: Detection using the fasting urinary nitrate:creatinine ratio
作者： Peter S. Grabowski , Amanda J. England , Roelf Dykhuizen , Mhairi Copland , Nigel Benjamin
关键词:
摘要: Objective. To develop a simple method for assessing endogenous nitric oxide (NO) production applicable to routine clinical practice in rheumatology. Methods. NO was assessed patients with rheumatoid arthritis (RA) as serum nitrate levels and the urinary nitrate:creatinine ratio morning samples of urine following an overnight fast. The influence dietary intake on these measurements investigated healthy volunteers. value validated infectious gastroenteritis, whom its is known be increased. Results. Urinary ratios were significantly elevated RA (average 3-fold elevation over controls; P < 0.005) or gastroenteritis 10-fold elevation, 0.001). Serum only (P Dietary had no significant fasting volunteers, showing that this parameter useful indicator production. Conclusion. We have developed procedure evaluating readily practice. Assessment will help our understanding role inflammatory conditions such RA.
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