Limitation and facilitation in the vectors and other aspects of the dynamics of filarial transmission: the need for vector control against Anopheles-transmitted filariasis.

摘要: In certain filaria-mosquito combinations the number of infective third-stage larvae (L3) that develop in a mosquito is not proportional to microfilariae (mff) ingested by mosquito. As mff increases yield L3 per microfilaria may either increase (in process known as facilitation) or decrease limitation). Each successful terms reaching haemocoel) (facilitation) decreases (limitation) permeability stomach wall for next microfilaria. Limitation seen some culicine mosquitoes especially Aedes spp. transmit Wuchereria bancrofti which consequence become relatively more efficient vectors they ingest fewer mff. This phenomenon makes interruption filarial transmission particularly difficult. survival anopheline adversely affected infection use mass drug administrations (MDA) reduce prevalence and intensity microfilaraemias mean life-span local Anopheles species. If these same species also act malarial parasites effective drug-based control W. worsen problem posed malaria. Therefore wherever malaria bancroftian filariasis are co-endemic caused transmitted MDA should be augmented interventions (use bednets house-spraying) against adult Anopheles. (authors)