Lipoproteins, cholesterol homeostasis and cardiac health.

摘要: Cholesterol is an essential substance involved in many functions, such as maintaining cell membranes, manufacturing vitamin D on surface of the skin, producing hormones, and possibly helping connections brain. When cholesterol levels rise blood, they can, however, have dangerous consequences. In particular, has generated considerable notoriety for its causative role atherosclerosis, leading cause death developed countries around world. Homeostasis centered metabolism lipoproteins, which mediate transport lipid to from tissues. As a synopsis major events proteins that manage lipoprotein homeostasis, this review contributes substantial attention recently been directed area. Despite intense scrutiny, majority phenotypic variation total related traits eludes explanation by current genetic knowledge. This somewhat disappointing considering heritability estimates established these highly genetic. Thus, continued search candidate genes, mutations, mechanisms vital our understanding heart disease at molecular level. Furthermore, marker development continues predict risk vascular illness, knowledge potential revolutionize treatment human disease.