Venetoclax-based chemotherapy in acute and chronic myeloid neoplasms: literature survey and practice points
作者： Naseema Gangat , Ayalew Tefferi
DOI: 10.1038/S41408-020-00388-X
关键词:
摘要: Venetoclax (VEN), a small-molecule inhibitor of B cell leukemia/lymphoma-2, is now FDA approved (November 2018) for use in acute myeloid leukemia (AML), specific to newly diagnosed elderly or unfit patients, combination with hypomethylating agent (HMA; including azacitidine decitabine) low-dose cytarabine. A recent phase-3 study compared VEN combined either placebo, the aforementioned population; complete remission (CR) and CR incomplete count recovery (CRi) rates were 28.3% 66.4%, respectively, an improvement overall survival was also demonstrated. VEN-based chemotherapy has shown activity relapsed/refractory AML (CR/CRi 33-46%), high-risk myelodysplastic syndromes (CR 39% treatment naive, 5-14% HMA failure), blast-phase myeloproliferative neoplasm 25%); all instances, additional fraction patients met less stringent criteria response. Regardless, venetoclax-induced remissions often short-lived (less than year) but long enough allow some transition allogeneic stem transplant. Herein, we review current literature on therapy both chronic malignancies provide outline procedures follow at our institution drug administration, monitoring adverse events dose adjustments.
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H Zhang, P M Nimmer, S K Tahir, J Chen, R M Fryer, K R Hahn, L A Iciek, S J Morgan, M C Nasarre, R Nelson, L C Preusser, G A Reinhart, M L Smith, S H Rosenberg, S W Elmore, C Tse, Bcl-2 family proteins are essential for platelet survival Cell Death & Differentiation. ,vol. 14, pp. 943- 951 ,(2007) , 10.1038/SJ.CDD.4402081
Xiaojia Niu, Guan Wang, Yue Wang, J Timothy Caldwell, Holly Edwards, Chengzhi Xie, Jeffrey W Taub, Chunhuai Li, Hai Lin, Yubin Ge, Acute myeloid leukemia cells harboring MLL fusion genes or with the acute promyelocytic leukemia phenotype are sensitive to the Bcl-2-selective inhibitor ABT-199. Leukemia. ,vol. 28, pp. 1557- 1560 ,(2014) , 10.1038/LEU.2014.72
David L. Vaux, Suzanne Cory, Jerry M. Adams, Bcl-2 gene promotes haemopoietic cell survival and cooperates with c-myc to immortalize pre-B cells. Nature. ,vol. 335, pp. 440- 442 ,(1988) , 10.1038/335440A0
M Andreeff, S Jiang, X Zhang, M Konopleva, Z Estrov, VE Snell, Z Xie, MF Okcu, G Sanchez-Williams, J Dong, EH Estey, RC Champlin, SM Kornblau, JC Reed, S Zhao, Expression of Bcl-2-related genes in normal and AML progenitors: changes induced by chemotherapy and retinoic acid Leukemia. ,vol. 13, pp. 1881- 1892 ,(1999) , 10.1038/SJ.LEU.2401573
Twee Tsao, Yuexi Shi, Steven Kornblau, Hongbo Lu, Sergej Konoplev, Ansu Antony, Vivian Ruvolo, Yi Hua Qiu, Ninaxiang Zhang, Kevin R. Coombes, Michael Andreeff, Kensuke Kojima, Marina Konopleva, Concomitant inhibition of DNA methyltransferase and BCL-2 protein function synergistically induce mitochondrial apoptosis in acute myelogenous leukemia cells Annals of Hematology. ,vol. 91, pp. 1861- 1870 ,(2012) , 10.1007/S00277-012-1537-8
Marina Konopleva, Rooha Contractor, Twee Tsao, Ismael Samudio, Peter P. Ruvolo, Shinichi Kitada, Xingming Deng, Dayong Zhai, Yue-Xi Shi, Thomas Sneed, Monique Verhaegen, Maria Soengas, Vivian R. Ruvolo, Teresa McQueen, Wendy D. Schober, Julie C. Watt, Tilahun Jiffar, Xiaoyang Ling, Frank C. Marini, David Harris, Martin Dietrich, Zeev Estrov, James McCubrey, W. Stratford May, John C. Reed, Michael Andreeff, Mechanisms of apoptosis sensitivity and resistance to the BH3 mimetic ABT-737 in acute myeloid leukemia Cancer Cell. ,vol. 10, pp. 375- 388 ,(2006) , 10.1016/J.CCR.2006.10.006
Y Tsujimoto, L. Finger, J Yunis, P. Nowell, C. Croce, Cloning of the chromosome breakpoint of neoplastic B cells with the t(14;18) chromosome translocation Science. ,vol. 226, pp. 1097- 1099 ,(1984) , 10.1126/SCIENCE.6093263
R Valdez, J Camoriano, V Fauble, R E Tiedemann, Y H Qiu, K R Coombes, M Cardone, E Braggio, H Yin, D O Azorsa, R A Mesa, A K Stewart, R Tibes, J M Bogenberger, S M Kornblau, W E Pierceall, R Lena, D Chow, C-X Shi, J Mantei, G Ahmann, I M Gonzales, A Choudhary, BCL-2 family proteins as 5-Azacytidine-sensitizing targets and determinants of response in myeloid malignancies Leukemia. ,vol. 28, pp. 1657- 1665 ,(2014) , 10.1038/LEU.2014.44
Adhra Al-Mawali, David Gillis, Ian Lewis, The role of multiparameter flow cytometry for detection of minimal residual disease in acute myeloid leukemia. American Journal of Clinical Pathology. ,vol. 131, pp. 16- 26 ,(2009) , 10.1309/AJCP5TSD3DZXFLCX
Anthony G. Letai, Rongqing Pan, Leah J. Hogdal, Juliana M. Benito, Donna Bucci, Lina Han, Gautam Borthakur, Jorge Cortes, Daniel J. DeAngelo, LaKeisha Debose, Hong Mu, Hartmut Döhner, Verena I. Gaidzik, Ilene Galinsky, Leonard S. Golfman, Torsten Haferlach, Karine G. Harutyunyan, Jianhua Hu, Joel D. Leverson, Guido Marcucci, Markus Müschen, Rachel Newman, Eugene Park, Peter P. Ruvolo, Vivian Ruvolo, Jeremy Ryan, Sonja Schindela, Patrick Zweidler-McKay, Richard M. Stone, Hagop Kantarjian, Michael Andreeff, Marina Konopleva, Selective BCL-2 Inhibition by ABT-199 Causes On-Target Cell Death in Acute Myeloid Leukemia Cancer Discovery. ,vol. 4, pp. 362- 375 ,(2014) , 10.1158/2159-8290.CD-13-0609