Pre-Clinical Traumatic Brain Injury Common Data Elements: Toward a Common Language Across Laboratories.

摘要: Abstract Traumatic brain injury (TBI) is a major public health issue exacting substantial personal and economic burden globally. With the advent of “big data” approaches to understanding complex systems, there potential greatly accelerate knowledge about mechanisms how detect modify them improve patient outcomes. High quality, well-defined data are critical success bioinformatics platforms, dictionary “common elements” (CDEs), as well “unique has been created for clinical TBI research. There no dictionary, however, preclinical research despite similar opportunities knowledge. To address this gap, committee experts was tasked with creating defined set elements further collaboration across laboratories enable merging meta-analysis. The CDEs were subdivided into Core module relevant most, if not all, studies, Injury-Model-Specific mo...