The anticancer properties of iron core-gold shell nanoparticles in colorectal cancer cells

摘要: Previously, iron core-gold shell nanoparticles (Fe@Au) have been shown to possess cancer-preferential cytotoxicity in oral and colorectal cancer (CRC) cells. However, CRC cell lines are less sensitive Fe@Au treatment when compared with lines. In this research, found decrease the viability of lines, including Caco-2, HT-29, SW480, through growth inhibition rather than induction death. The induced by cells uses different subcellular pathways mitochondria-mediated autophagy Fe@Au-treated cells, OECM1. Interestingly, Caco-2 line shows a similar response OECM1 is thus more other studied. We investigated underlying resistance mechanisms does not result from total amount internalized. Instead, amounts Fe Au internalized appear determine Fe-only Fe@Au-resistant Fe@Au-sensitive only moderately cytotoxic effect on highly appears arise cells' relative insensitivity Fe, as demonstrated our treatments. This surprising outcome, given that has far considered be "active" component nanoparticles. we coatings, previously passivating coating protect cores oxidation, significantly enhance certain Therefore, conclude both these core-shell essential for anticancer properties observed