Pharmacological treatment of unipolar depression.

摘要: Antidepressants were first developed serendipitously 60 years ago and gave rise to the monoamine hypothesis of depression antidepressant action which has persisted in various forms ever since. Although we have made huge strides our understanding pharmacology antidepressants, neuroscience depression, current antidepressants changed little since original drugs. In this chapter I review some controversies use drugs including whether they actually work, then go on describe state clinical looking both at principles practice treatment reviewing evidence for efficacy, tolerability safety acute sequenced treatments. finally briefly consider future directions aspiration developing more effective antidepressants.