Pro-Inflammatory Mediators and Human Skin Disease

摘要: Human skin diseases are many and diverse in nature, ranging from conditions where the primary abnormality is a transient disorder of vasculature, one example being urticaria, to such as psoriasis, which characterised by chronic cellular infiltrate. It has been suggested that pathological changes associated with these may be brought about chemical mediators present involved tissue. Before any aspect disease pathology ascribed actions particular compound, however, certain criteria must first satisfied. The mediator, should identified lesional tissue and, ideally, absolute amounts compared those clinically normal skin. If other compounds similar modes also it useful ascertain relative each since, although mediator considerably less potent eliciting response, difference potency rendered little importance if compound correspondingly greater vivo. ability cells derived produce vitro following stimulation suggests release resident cell population contribute endogenous levels measured, whether event evolution lesion, or occurs secondarily response damage cannot readily determined.