Non-functioning pituitary tumors: 2012 update.

摘要: Abstract Non-functioning pituitary adenomas are the most common macroadenomas in adults, accounting for approximately 14–28% of all clinically relevant tumors. They a heterogeneous group tumors that cause symptoms by compression and/or hormone deficiencies. The possibility tumor growth is increased and solid as compared to microadenomas cystic Diagnosis based on imaging procedures (magnetic resonance imaging), but there studies reporting promising potential biomarkers. Transsphenoidal surgery remains first therapeutic option large with compressive symptoms. There no evidence endoscopic improve outcomes, they decrease morbidity. unanimity finding prognostic predictors recurrence. Radiosurgery achieves control and, sometimes, adenoma size reduction. Its adverse effects increase higher doses sizes >4 cm3. Drug treatment little value. In aggressive non-functioning tumors, temozolomide (TMZ) may be used caution because controlled available. TMZ 38–40% optimal regimen duration have not been defined yet. Lack response after 3 cycles predicts resistance, initial does ensure mid or long-term results. O6-methylguanine-DNA methyltransferase expression has limited predictive value It should therefore determinant factor selection patients treated TMZ.