Sphingosine analogue FTY720 sensitizes arsenic trioxide-induced autophagic cell death in human malignant glioma cells

摘要: Malignant gliomas are known to be resistant therapies that induce apoptosis. Recently, several lines of evidence indicate glioblastoma cells may less autophagy. Therefore, drugs targeting autophagy considered as promising in the management malignant gliomas. The purpose this study was investigate antitumour potential FTY720, a novel sphingosine analogue, and elucidate molecular mechanism its cytotoxic effects on glioma cells. We demonstrate FTY720 induces but not apoptosis found sensitizes arsenic trioxide-induced autophagic cell death – trioxide (ATO) combined treatment through inhibition Akt/mTOR signalling pathway. Our findings provide possible base for combinatorial therapeutic application ATO