Cardiovascular parameters in a mixed-sex swine study of severe decompression sickness treated with the emulsified perfluorocarbon Oxycyte

摘要: Intravenous perfluorocarbons (PFC) have reduced the effects of decompression sickness (DCS) and improved mortality rates in animal models. However, concerns for physiological DCS combined with PFC therapy not been examined a balanced mixed-sex population. Thirty-two (16 male, 16 female) instrumented sedated juvenile Yorkshire swine were exposed to 200 feet seawater (fsw) 31 min hyperbaric air. Pulmonary artery pressure (PAP), cardiac output (CO), systemic arterial (SAP) monitored before (control) after exposure. Animals randomized treatment Oxycyte (5 ml/kg; Oxygen Biotherapeutics, Inc., Morrisville, NC) vs. saline 100% oxygen administered upon onset; animals observed 90 min. Parameters recorded analyzed included PAP, CO, SAP. In all PAP began rise prior cutis marmorata (CM) onset, first sign clinical DCS, generally peaking CM onset. Female swine, compared castrated males, had more rapid onset (7.30 11.46 postsurfacing) earlier maximal (6.41 9.69 post-CM onset). was associated sustained elevation above controls both sexes (33.41 25.78 mmHg). Significant pattern differences SAP noted between therapeutic groups. There no statistically significant survival or paralysis control groups during 48-h observation period. conclusion, is prolonged increase swine. These species sex warrant further exploration.