摘要: The Wnt/beta-catenin pathway is involved in various cellular activities--including determination, proliferation, migration and differentiation--in embryonic development adult homeostasis. deregulation or constitutive activation of the may lead to cancer formation. This review focuses on role canonical signaling melanocyte lineage, more specifically, melanoma. Several components pathway, such as APC, ICAT, LEF1 beta-catenin are modified melanoma tumors cell lines, leading this signaling. A hallmark presence nucleus. Indeed, found about 30% human nuclei, indicating a potentially specific for aggressive type cancer. Beta-catenin can induce ubiquitous genes myc cyclinD1, lineage-restricted Brn2 melanocyte-specific Mitf-M Dct. Brn-2 encode transcription factors. Mitf plays critical survival, proliferation differentiation. proliferation. Determining how alone with other pathways, orchestrates induction target diverse range activities represents major challenge research into formation tumor progression.
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