Does vitamin D affect the association between FTO rs9939609 polymorphism and depression
作者： Maryam Gholamalizadeh , Mohammad Hassan Eftekhari , Mahsa Mehrdad , Hossein-Ali Nikbakht , Fatemeh Jafari
DOI: 10.1080/17446651.2021.1889367
关键词:
摘要: Background & objectives: Depression is a highly prevalent and multifactorial psychological disorder. Fat Mass Obesity-Associated (FTO) gene the serum vitamin D level are proposed to be involved in pathophysiology of depression. This study aimed investigate interactions between one FTO single nucleotide polymorphism, depression, overweight adults.Methods: One hundred ninety-seven adults were recruited this cross-sectional study. genotyping was performed by amplification refractory mutation system polymerase chain reaction (ARMS-PCR). severity assessed using Beck's depression inventory (BDI-II). Serum levels measured direct competitive enzyme-linked immunosorbent assay (ELISA) method.Results: A-allele carriers had higher score (P = 0.03). Multivariate regression models showed positive association rs9939609 polymorphism no effect on genotype depression.Conclusion: might associated with independent level. Further longitudinal studies needed confirm these results.
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